Scientists Invent New Treatment for Trichonomas Gallinae Infections Using the Hettich ROTANTA 460
Michael Hess, Ivana Bilic, Abdel-Mageed Amin Aziza Abdel-Fattah invented a new treatment for trichomonas gallinae infections using cysteine protease inhibitors. Their patented publication, entitled “Protease inhibitors for treating trichomonas gallinae infections”, details the materials and methodology used during their experimentation process. The Hettich ROTANTA 460 benchtop centrifuge was employed for the propagation of T. gallinae.
According to the paper, “Trichomonas gallinae is a flagellated protozoan parasite which infects a variety of birds all over the world.” “The parasite produces a variety of pathological changes depending on the virulence of the strain and the species of bird infected.” “Avian trichomonosis, caused by T. gallinae, has been reported from several continents as a major disease for numerous avian species of the orders Columbiformes, Falconiformes and Psittacifomes.”
The patent states that the object of the invention is to: “provide suitable means for combatting infections with T. gallinae in birds.” “… It is demonstrated that the progression of avian trichomonosis is linked with the presence of cysteine peptidases which can be neutralized by co-application of peptidase inhibitors without toxicity to the host.” “… With the present invention it is demonstrated that the progression of avian trichomonosis is linked with the presence of cysteine peptidases which can be neutralized by co-application of peptidase inhibitors without toxicity to the host.”
During propagation of T. gallinae, axenic clonal cultures were grown and incubated for 24 hours before being centrifuged at 3,300 x g for 5 minutes via the Hettich ROTANTA 460.
Hettich offers a wide range of laboratory centrifuges for clinical, research, and industrial applications. The ROTANTA 460 is a high-capacity, high-throughput benchtop centrifuge supported by a variety of accessories. To learn about application-specific ROTANTA 460 packages, visit http://www.hettweb.com/hettich-rotanta-460-centrifuge.html.