Study on the Functions of Nitric Oxide and Other Gaseous Mediators Employed Hettich UNIVERSAL 32R Centrifuge

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25
April
2014

Study on the Functions of Nitric Oxide and Other Gaseous Mediators Employed Hettich UNIVERSAL 32R Centrifuge

Study on the Functions of Nitric Oxide and Other Gaseous Mediators Employed Hettich UNIVERSAL 32R Centrifuge

The Hettich UNIVERSAL 32R benchtop centrifuge was used for sample treatment and preparation in the study “The Role of Nitric Oxide and other Gaseous Mediators in Cardiovascular Disease Models: Emphasis on Septic Shock” by Farhana Anuar of the University of Singapore.

In the study, the effects of flurbiprofen (FLU) and its nitric oxide (NO) releasing derivative, nitroflurbiprofen (NOF), were evaluated in a caecal ligation puncture (CLP) model of septic shock in laboratory rats. The Hettich UNIVERSAL 32R was used for processing blood samples and culturing cell media obtained from the rats.

Ultimately, the results of the study “suggest a novel, protective effect of both FLU and NOF in the CLP model of septic shock.” The study continues that “both NOF and 1400W [a NOS inhibitor] are able to down regulate the biosynthesis of pro-inflammatory H2S [liver hydrogen sulphide]…” “Hence the protea some may be intricately linked in the ‘cross talk’ between NO and H2S and may prove to be a novel approach to the treatment of septic/endotoxic shock and perhaps other inflammatory disorders.”

Hettich’s comprehensive line of centrifuges enables scientists to conduct important testing and research, such as this study on the effects of gaseous mediators on septic shock. The Hettich UNIVERSAL 32R is a versatile, quiet, safe and reliable centrifuge that is suited for many applications in clinical, research and industrial laboratories.

Learn more about the Hettich Universal 320 R benchtop centrifuge at http://www.hettweb.com/hettich-universal-320-centrifuge.html.

Categories: Clinical

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